Low-intensity pulsed ultrasound in dentofacial tissue engineering - PubMed
Oral and maxillofacial diseases affect millions of people worldwide and hence tissue engineering can be considered an interesting and clinically relevant approach to regenerate orofacial tissues after being affected by different diseases. Among several innovations for tissue regeneration...
pubmed.ncbi.nlm.nih.gov
Non-invasive modality such as LIPUS therapy has been given increased attention and raised as promising therapeutic tool for the regeneration of orofacial tissues. LIPUS presents low toxicity, low immunogenicity, non-invasiveness, highly targeted selectivity, and repeated applicability. Although LIPUS therapy has been widely used in the medical fields such as orthopedic surgery and rehabilitation, its availability and potential by dental professionals are still on initial stage. The effects of LIPUS in bony tissue seem to be well understood, but the literature has still lacked for available information about its effects on temporomandibular joint components and periodontal tissues. The present review provides current evidences that LIPUS has a positive effect on dental and periodontal cells metabolism and tissues repair, suggesting that LIPUS can be a promising therapeutic tool for the regeneration of tooth tissues. An understanding of the bioeffect of LIPUS therapy on orofacial tissues as described in this review is essential to the successful integration of management remedies for tissue engineering. To develop an evidence-based approach to clinical trials for treatment for orofacial degenerative diseases, we would like to be in full pursuit of LIPUS biotherapy. Still, there are many challenges for this relatively new strategy, but its achievements promise to go far beyond the present possibilities. Although there is a consensus in the literature about the stimulatory effect of LIPUS on different cell type, the optimum LIPUS parameter for each cell type has not yet been identified. Future comparative studies that can identify these optimum LIPUS treatment condition for each cell type are recommended.
