Effects of Aspirin on Odontogenesis of Human Dental Pulp Cells and TGF- β 1 Liberation from Dentin In Vitro - PubMed
This <i>in vitro</i> study demonstrated that ASA, especially in high concentrations, promoted the odontogenesis of HDPCs and TGF-<i>β</i>1 liberation from dentin, showing the potential of being incorporated into the novel pulp capping materials for dental tissue regeneration.
pubmed.ncbi.nlm.nih.gov
Results: The results showed that 25-50 μ·g/mL ASA promoted mitochondrial activity of HDPCs at 72 h (P < 0.05) and yielded significantly higher proliferation rates of HDPCs than the control at 14d and 21d (P < 0.001). All concentrations of ASA promoted odontogenic differentiation of HDPCs by enhancing the levels of DSP and RUNX2, their mRNA expression, and mineralization in a dose-dependent manner. Also, ASA yielded significantly higher TGF-β1 liberation after conditioning dentin for 5 min (25, 200 μ·g/mL; P < 0.001) and 10 min (200 μ·g/mL; P < 0.05).
Conclusions: This in vitro study demonstrated that ASA, especially in high concentrations, promoted the odontogenesis of HDPCs and TGF-β1 liberation from dentin, showing the potential of being incorporated into the novel pulp capping materials for dental tissue regeneration.
