Patients using a cream containing tretinoin, a retinoid commonly used to treat acne and other conditions, appeared more likely to die than those using a placebo in a clinical trial that was halted early as a result, according to a new report. However, evidence does not suggest these excess...
www.sciencedaily.com
"Vitamin A is such a basic metabolic factor, in the brain and endocrine glands, liver and kidneys, etc., I think it's dangerous to experiment with drugs that interfere with it."
It helps, the thing is, most supplementable pregnenolone isn't very pure. You don't need to anyways if your thyroid is functioning correctly, and you've got sufficient cholesterol and vitamin A to synthesize it.