if you blocked sex hormones (androgens and estrogens alike) and made your hormones pre-pubital, would this slow ageing? theres a lot of evidence castration increases lifespan and slows ageing, but this prevents puberty. but blocking sex hormones in adults could work as well. the idea of the disposable soma theory of ageing is that more effort spent on growth and reproduction related processes leads to less ability to repair and maintain health (youth) increaseing ageing.
this in sheep suggests castration works by cumulatively slowing ageing rather than preventing sexual maturity so it implying blocking sex hormones would help adults age slower
"For instance, the average DNAm deceleration is increased by an additional 1.2 months when considering individuals aged beyond 2.9 years. In contrast, we saw no difference between castrated and intact males younger than 18 months. Together this implies that the effects of androgen exposure on the epigenome and aging are cumulative."
im interested in other hormonal differences between children and adults as blocking sex hormones drastically would have consequences
this in sheep suggests castration works by cumulatively slowing ageing rather than preventing sexual maturity so it implying blocking sex hormones would help adults age slower
"For instance, the average DNAm deceleration is increased by an additional 1.2 months when considering individuals aged beyond 2.9 years. In contrast, we saw no difference between castrated and intact males younger than 18 months. Together this implies that the effects of androgen exposure on the epigenome and aging are cumulative."
im interested in other hormonal differences between children and adults as blocking sex hormones drastically would have consequences